A population-based, prospective cohort study revealed that a trajectory of increasing disability became significantly steeper after stroke but not after myocardial infarction (MI). The study included 5888 individuals 65 years or older from 1989 to 2013, mean age was 72.8 years; 2495 were male. During a mean follow-up of 13 […]
An international consortium showed that patients with depression and increased appetite and/or weight (A/W) carried a higher number of genetic risk variants for body mass index (BMI) and levels of C-reactive protein (CRP) and leptin. Data sets were drawn from case-control, cohort, and population-based studies, with established psychiatric diagnoses and […]
A stiff neck typically is the result of muscles weakening over time from poor posture or misuse, and your body has a protective spasm. Simple remedies include: Use ice for the first 48 to 72 hours, then use heat; take over-the-counter pain relievers; keep moving, but avoid jerking or painful […]
A randomized, double-blind trial of canakinumab targeting interleukin-1β innate immunity pathway revealed a significantly lower rate of recurrent cardiovascular events in patients of myocardial infarction (MI). The trial included 10,061 patients with previous MI and a high-sensitivity C-reactive protein （hsCRP） level of 2 mg or more per liter. Canakinumab (at […]
A prospective, randomized, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial concluded that a 800 mg/day pharmaceutical-grade Chondroitin sulfate (CS) is superior to placebo and similar to celecoxib in reducing pain and improving function over 6 months in symptomatic knee osteoarthritis (OA) patients. The trial included 604 patients of knee osteoarthritis in […]
A panel of experts made a strong recommendation against the use of arthroscopy in nearly all patients with degenerative knee disease, based on linked systematic reviews. The recommendation applies to patients with or without imaging evidence of osteoarthritis, mechanical symptoms, or sudden symptom onset. Degenerative knee disease is a chronic […]