Growing body of evidence supports that increasing adiposity has a detrimental association with cardiovascular disease (CVD) and longevity. The association of body mass index (BMI) with CVD appeared more susceptible to confounding due to pre-existing comorbidities. Associations of waist circumference, waist-to-hip ratio, waist-to-height ratio, and percentage body fat mass with […]
A randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, showed that a select group of short-chain fatty acid (SCFA)-producing strains of the gut microbiota was promoted by dietary fibers, and correlated with improved blood-glucose regulation in type 2 diabetes mellitus (T2D). The improvement in hemoglobin […]
A randomized chemoprevention study in the US found evidence that calcium and vitamin D supplementation increased the risk of sessile serrated adenomas or polyps (SSA/Ps), precursor lesions for colorectal cancer. A total of 2259 participants with one or more adenoma at baseline were randomized to receive 1200 mg/day of elemental calcium, […]
A randomized, open, crossover trial in Italy showed that both low-calorie lacto-ovo vegetarian diet (VD) and Mediterranean diet (MD) were effective in reducing body weight, body mass index (BMI), and fat mass. One hundred eighteen overweight subjects (mean age 51.1 years, females 78%, BMI ≥ 25) with a low-to-moderate cardiovascular […]
A randomized clinical trial in the US showed that there was no significant difference in weight change between a healthy low-fat diet (HLF) vs a healthy low-carbohydrate diet (HLC), and neither genotype pattern nor baseline insulin secretion was associated with the dietary effects on weight loss. A total of 609 […]
A systematic review and meta-analysis suggested that replacing sitting with standing could be a potential solution for a sedentary lifestyle to prevent weight gain in the long term. The analysis included 46 studies with 1184 participants. The mean difference in energy expenditure (EE) between sitting and standing was 0.15 kcal/min (0.1 and […]
A systematic review and meta-analysis suggests that adherence to a Mediterranean diet is associated with significantly lower risk of incident frailty in older people. The analysis included four studies, 5,789 community-dwelling older adults (mean age ≥60), with mean follow-up of 3.9 years. Greater adherence to a Mediterranean diet was associated […]
An open-label, cluster-randomized trial in the UK showed that intensive weight management achieved remission of type 2 diabetes (T2D). The trial included 306 patients from 49 general practices between July 25, 2014, and Aug 5, 2017. The patients aged 20–65 years who had been diagnosed with T2D within the past […]
A meta-analysis of randomized clinical trials concluded that healthy lifestyle modifications (LSM, eating healthier diets and exercising) successfully reduced diabetes incidence and sustained for several years in adults at risk for diabetes. The analysis included 43 studies published between January 1, 1990, and January 1, 2015; 49 029 participants at risk […]
The US Food and Drug Administration warns moderation on licorice, or liquorice, a low-growing shrub mostly grown for commercial use in Greece, Turkey, and Asia. It is in black licorice and has been used as a treatment for heartburn, stomach ulcers, bronchitis, sore throat, cough and some infections caused by […]