Cardiovascular Diseases

Bleeding Risk with Aspirin Increased with Age

This entry was posted in Cardiovascular Diseases and tagged Bleeding; Aspirin; Age; CVD on by

A UK prospective population-based study of long-term antiplatelet treatment (predominantly daily aspirin 75 mg enteric coated) in secondary prevention of vascular disease showed that the severity, case fatality, and poor functional outcome of bleeds increased with age, and that in patients aged 75 years or older, most major upper gastrointestinal […]

Lithium Use in Early Pregnancy Linked to Congenital Cardiac Defects

This entry was posted in Cardiovascular Diseases Mental Disorders and tagged Lithium; Early Pregnancy; Congenital Cardiac Defects on by

A US cohort study suggested that maternal use of lithium during the first trimester was associated with an increased risk of cardiac malformations, including Ebstein’s anomaly (right ventricular outflow tract obstruction defects). The study included 1,325,563 pregnancies in women who delivered a live-born infant between 2000 and 2010. Cardiac malformations […]

Intensive BP Control Supported

This entry was posted in Cardiovascular Diseases and tagged Hypertension Intensive Blood Pressure Control on by

A systematic review and network meta-analysis, which allowed the simultaneous comparison of multiple achieved systolic blood pressure (SBP) levels on clinical outcomes while preserving trial-level treatment randomization, indicates that treating patients to reduce SBP below currently recommended targets may significantly reduce risk of cardiovascular disease (CVD) and all-cause mortality, with […]

Early Onset Hypertension Linked to Risks and Heritability

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A multigenerational, prospective cohort study in the US concluded that early onset (age <55 years) compared with late onset hypertension was associated with greater odds of cardiovascular death and with greater risk for hypertension in offspring. The study included 3614 first generation participants with mortality data and 1635 initially non-hypertensive […]

NSAIDs Increase Heart Attack Risk

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Systematic review followed by an individual patient data meta-analysis concluded that all non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, were found to be associated with an increased risk of acute myocardial infarction (AMI). Risk of AMI with celecoxib was comparable to that of traditional NSAIDS and was lower than for rofecoxib. […]

Cooling for the Revived to Reduce Brain Injury

This entry was posted in Cardiovascular Diseases and tagged Brain Injury Cardiopulmonary Resuscitation Cooling on by

The American Academy of Neurology issued practice guideline to reduce brain injury following cardiopulmonary resuscitation. The guideline was developed after reviewing relevant published literature from 1966 to August 29, 2016. For patients who are comatose in whom the initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or ventricular fibrillation […]