Some Birth Defects Linked with Paroxetine or Fluoxetine帕罗西汀或氟西汀与某些出生缺陷有关

A Bayesian analysis combining results from a multicenter population based case-control study of birth defects provided reassuring evidence for some selective serotonin reuptake inhibitors (SSRIs) but suggested that some birth defects occur 2-3.5 times more frequently among the infants of women treated with paroxetine or fluoxetine early in pregnancy. The study included 17 952 mothers of infants with birth defects and 9857 mothers of infants without birth defects in 10 centers in the US, with estimated dates of delivery between 1997 and 2009. High posterior odds ratios excluding the null value were observed for five birth defects with paroxetine and for two defects with fluoxetine. Source: http://www.bmj.com/一项贝叶斯分析综合了关于出生缺陷的多中心以人口为基础的病例对照研究结果，对某些选择性五羟色胺再摄取抑制剂（SSRIs）提供了令人欣慰的证据，但提示孕早期经帕罗西汀或氟西汀治疗妇女的婴儿，某些出生缺陷发生率增加了2-3.5倍。该研究纳入了美国10个医疗中心17952名有出生缺陷婴儿的母亲和9857名无出生缺陷婴儿的母亲，预产期在1997年和2009年间。用帕罗西汀者五个出生缺陷的机率增高，用氟西汀者两个出生缺陷的机率增高。来源：http://www.bmj.com/