A retracted and republished report of a primary prevention study in Spain reaffirmed that an energy-unrestricted Mediterranean diet supplemented with extra-virgin olive oil or nuts lowered rate of major cardiovascular events than a reduced-fat diet in persons at high risk for cardiovascular disease (CVD). The study included 7447 participants (55 […]
An ongoing study in the UK revealed that systolic blood pressure (SBP) ≥130 mmHg at age 50 is associated with increased risk of dementia, independent of cardiovascular disease (CVD). Systolic and diastolic blood pressure were measured on 8639 persons (32.5% women) in 1985, 1991, 1997, and 2003. Incidence of dementia (n […]
A long term cohort study in the US revealed that obesity remains a risk factor for cardiovascular disease (CVD), even when metabolic health is maintained during long periods of time. A large proportion of metabolically healthy women converted to an unhealthy phenotype over time across all BMI categories, which is […]
A systematic review found that exercising for at least 52 hours (averaging about an hour, 3 times a week) is associated with improved cognitive performance in older adults with and without cognitive impairment. Another population-based study in Chinese suggested that active participation in intellectual activities might help prevent dementia in […]
A Dutch population-based study revealed that a better diet quality is associated with larger brain tissue volumes. The study included 4,447 participants (average age 65.7; female 56.8%) underwent dietary assessment and brain MRI scanning between 2005 and 2015, excluding participants with an implausible energy intake, prevalent dementia, or cortical infarcts. […]
A Spanish study identified that cardiomyopathy-associated genes titin truncating variants (TTNtv) represent a prevalent genetic predisposition for alcoholic cardiomyopathy (ACM), and are also associated with a worse left ventricular ejection fraction in dilated cardiomyopathy (DCM) patients who consume alcohol above recommended levels. The study included 141 ACM cases, 716 DCM […]
A prospective cohort study in the US revealed that greater depressive symptoms were associated with worse episodic memory, smaller cerebral volume, and silent infarcts. The study included 1,111 stroke-free older adults with an average age of 71 between 2003 and 2008, 52% were Caribbean Hispanic. 22% of participants had greater […]
A US cohort study found that the neutrophil-to-lymphocyte ratio (NLR) was prospectively associated with all-cause mortality and cardiovascular disease (CVD). A Duffy antigen variant locus, a common genetic variant of African origin, was associated with a lower baseline NLR and modified the associations. The study included a population-based longitudinal cohort […]
A study in US adults concluded that a healthy lifestyle could substantially reduce premature mortality and prolong life expectancy. The study included 123,329 adults and defined 5 low-risk lifestyle factors as never smoking, body mass index of 18.5 to 24.9 kg/m2, ≥30 min/d of moderate to vigorous physical activity, moderate […]
A genome-wide association meta-analysis identified 44 independent and significant loci associated with major depression. The analysis was based in 135,458 cases and 344,901 controls. Lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or […]