Data from a multi-center longitudinal, prospective, general Canadian population birth cohort study provide insight of the infant microbiome that may be predictive of allergic diseases. Deeply phenotyped participants in the birth cohort (n = 1115) were compared to non-allergic comparator group. There are early-life influences and microbiome features which are uniformly associated […]
A double-blind, double-dummy, randomized trial in European countries revealed that among patients with atrial high-rate episodes (AHREs) detected by implantable devices, anticoagulation with edoxaban led to a higher incidence of a composite of death or major bleeding but did not significantly improve efficacy outcomes. A total of 2536 patients 65 […]
A UK pragmatic, superiority, open label, randomized controlled trial of sleep restriction therapy (SRT) versus sleep hygiene concluded that brief primary care nurse delivered SRT is both clinically effective and cost-effective in treating insomnia disorder and improving other aspects of mental health and functioning. A total of 642 participants (mean […]
A UK prospective cohort study in patients with symptoms suggestive of stable angina suggested that cardiac troponin predicts risk of myocardial infarction or cardiovascular death independent of cardiovascular risk factors and disease severity. The study included 4,240 patients (mean age 66 years, 33% female), coronary artery disease (CAD) was identified […]