A pooled analysis of individual patient data suggested that low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and higher doses of aspirin were only effective in patients weighing 70 kg or more. The analysis included 117 279 participants in […]
A US prospective clinical-pathologic study revealed that late in life both higher average and faster decline in blood pressure (BP) are related to cardiovascular and/or Alzheimer disease (AD). The study included 1,288 persons (mean age at death = 88.6 years; 65% women, mean follow-up 8 years). Each participant had BP […]
Reflex syncopes include vasovagal, carotid sinus, and situational syncope, share a common pathophysiology: an abrupt slowdown of the heart rate and a dilatation of the blood vessels leading to hypo-perfusion of the brain. Pain, seeing blood, emotional reaction, and prolonged standing are triggers of vasovagal syncope. Situational is triggered by […]
A US registry for fibromuscular dysplasia (FMD) revealed that patients with multifocal FMD diagnosed at an older age may have a more benign phenotype. For a total of 1016 patients included in the analysis as of December 15, 2016, 170 (16.7%) were 65 years or older at the time of […]
A mendelian randomization analysis revealed that Lipoprotein(a) [ Lp(a)]concentration must be lowered by approximately 100 mg/dL to achieve the same reduction in coronary heart disease (CHD) risk as can be achieved by lowering low-density lipoprotein cholesterol (LDL-C) level by 38.67 mg/dL. The analysis involved more than 80 000 patients and more […]
A prospective cohort study in the US revealed that adherence to a healthy lifestyle is associated with a substantially lower risk of cardiovascular disease (CVD) incidence and mortality among adults with type 2 diabetes (T2D). The study included 11,527 participants (8,970 women) with T2D diagnosed during follow-up of an average […]
A retracted and republished report of a primary prevention study in Spain reaffirmed that an energy-unrestricted Mediterranean diet supplemented with extra-virgin olive oil or nuts lowered rate of major cardiovascular events than a reduced-fat diet in persons at high risk for cardiovascular disease (CVD). The study included 7447 participants (55 […]
An ongoing study in the UK revealed that systolic blood pressure (SBP) ≥130 mmHg at age 50 is associated with increased risk of dementia, independent of cardiovascular disease (CVD). Systolic and diastolic blood pressure were measured on 8639 persons (32.5% women) in 1985, 1991, 1997, and 2003. Incidence of dementia (n […]
A long term cohort study in the US revealed that obesity remains a risk factor for cardiovascular disease (CVD), even when metabolic health is maintained during long periods of time. A large proportion of metabolically healthy women converted to an unhealthy phenotype over time across all BMI categories, which is […]
A systematic review found that exercising for at least 52 hours (averaging about an hour, 3 times a week) is associated with improved cognitive performance in older adults with and without cognitive impairment. Another population-based study in Chinese suggested that active participation in intellectual activities might help prevent dementia in […]