An US prospective cohort study revealed that orthostatic hypotension (OH) in midlife was independently associated with incident dementia and ischemic stroke. The study included 11,709 participants without a history of coronary heart disease or stroke at the baseline examination (1987–1989, mean age 54). OH was defined as a drop in […]
A randomized noninferiority trial in Australia suggested that intermittent energy restriction is an effective alternative diet strategy for the reduction of hemoglobin A1c (HbA1c) level comparable to continuous energy restriction in patients with type 2 diabetes (T2D), and it may be superior to continuous energy restriction for weight loss. The […]
An UK study found that bolus water drinking is superior to other nonpharmacological interventions for older people with orthostatic hypotension (OH). A total of 150 orthostatic challenges were performed in 25 older people (age 60–92 years). The response rate (of participants whose systolic blood pressure [SBP] drop improved by ≥10 […]
A pooled analysis of individual patient data suggested that low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and higher doses of aspirin were only effective in patients weighing 70 kg or more. The analysis included 117 279 participants in […]
A US prospective clinical-pathologic study revealed that late in life both higher average and faster decline in blood pressure (BP) are related to cardiovascular and/or Alzheimer disease (AD). The study included 1,288 persons (mean age at death = 88.6 years; 65% women, mean follow-up 8 years). Each participant had BP […]