A genome-wide association meta-analysis identified 44 independent and significant loci associated with major depression. The analysis was based in 135,458 cases and 344,901 controls. Lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or […]
A prospective Swedish study suggests that nuts consumption or factors associated with it may play a role in reducing the risk of atrial fibrillation. The study included 61 364 Swedish adults followed up for 17 years. There was an inverse association between nuts consumption and incident atrial fibrillation, and remained […]
The US Preventive Services Task Force has updated recommendations of exercise, but not vitamin D for fall prevention interventions in community-dwelling older adults. According to a systematically review of 62 randomized clinical trials (N = 35 058), multifactorial intervention trials were associated with a reduction in falls (incidence rate ratio [IRR], 0.79). Exercise […]
A cohort study in the US suggested prenatal selective serotonin reuptake inhibitor (SSRI) exposure was associated with changes in fetal brain structure and activity, particularly in brain regions critical to emotional processing. The study included 98 infants: 16 with in utero SSRI exposure, 21 with in utero untreated maternal depression […]
Antidepressants have helped millions of people ease depression and anxiety, but they are not harmless. Many people stop the medications without significant trouble. Some people have significant withdrawal symptoms, and make tiny reductions over a long period of time may help to quit. The drugs initially were approved for short-term […]
A Danish study suggests that weight loss from childhood to early adulthood can reduce the increased risks of type 2 diabetes (T2D) among overweight and obese boys. The study included 62,565 Danish men. Overweight was defined as body mass index ≥17.38 at age 7, ≥21.82 at age 13, and ≥25 […]
A Canadian cohort study suggested that congenital heart defects in offspring may be an early marker of predisposition to cardiovascular disease (CVD). The study included 1 084 251 women who had delivered infants between 1989 and 2013, with follow-up extending up to 25 years past pregnancy. Women whose infants had […]