A mendelian randomization study concluded that a genetic predisposition to higher serum calcium levels was associated with increased risk of coronary artery disease (CAD) and myocardial infarction (MI). The study included 60 801 CAD cases (approximately 70% with MI) and 123 504 noncases, with baseline data collected from 1948 and populations derived […]
A US cohort analysis revealed that moderate weight gain from 18 or 21 to 55 years old was associated with significantly increased risk of major chronic diseases and mortality. A total of 92 837 women (97% white; mean weight gain: 12.6 kg over 37 years) and 25 303 men (97% white; mean […]
A US study showed that improved diet quality over 12 years was consistently associated with a decreased risk of death. The study used Cox proportional-hazards models to calculate adjusted hazard ratios for total and cause-specific mortality among 47,994 women and 25,745 men from 1998 through 2010, with changes in diet […]
http://jamanetwork.com/The cross-sectional baseline data from a population-based cohort study in UK identified associations between body mass index (BMI) and risk of hypertension, coronary heart disease, type 2 diabetes, and elevated systolic and diastolic blood pressures. The study included 119 859 participants with complete phenotypic (medical and sociodemographic) and genetic data between […]