An US 2nd phase randomized clinical trial revealed that maintenance of antidepressant medication treatment was associated with a reduced risk of depressive recurrence, but previous treatment with cognitive behavioral therapy (CBT) was not. The study included a total of 292 adult outpatients (171 women; mean age, 45.1 years) with chronic […]
A meta-analysis of individual participant data from eligible observational studies suggested that use of any antihypertensive medications (AHM) with efficacy to lower blood pressure (BP) might reduce the risk for dementia among people with high BP. However, no evidence was found that a specific AHM drug class was more effective […]
A prospective longitudinal cohort study in Britain revealed that early adulthood vascular risk is strongly associated with smaller whole-brain volume (WBV) and greater white matter–hyperintensity volume (WMHV) at age 69 to 71 years. The study assessed 502 participants in a birth cohort in 1946. Framingham Heart study–cardiovascular risk scores (FHS-CVS) […]
A meta-analysis and systematic review suggested that optimism is associated with a lower risk of events of cardiovascular diseases (CVD) and all-cause mortality. The analysis included 15 studies of 229 391 participants, in which 10 studies reported data on CVD events (including CVD mortality, nonfatal myocardial infarction, stroke, and/or new-onset angina) […]
A prospective population-based cohort study in the Netherlands suggests that in individuals at low and intermediate genetic risk, favorable modifiable-risk profiles are associated with a lower risk of dementia compared to unfavorable profiles. However, these protective associations were not found in those at high genetic risk. The study included 6,352 […]
A UK epidemiological study revealed that high and increasing blood pressure (BP) from early adulthood into midlife seems to be associated with increased white matter hyperintensity volume (WMHV) and smaller brain volumes at 69–71 years of age. The study included 502 individuals from a cohort born throughout mainland Britain in […]
Two US studies showed that more intensive blood pressure (BP) management was associated with less progression of cerebral small vessel ischemic diseaseand a greater decrease in total brain volume; BP patterns in midlife and late life may be associated with differing risks for incident dementia. The substudy of a randomized […]
Two observational cohort studies revealed that altered levels of hemoglobin and liver function markers were associated with Alzheimer disease (AD). The first study included 12,305 participants without dementia of the population-based Dutch cohort (mean age 64.6 years, 57.7% women). During a mean follow-up of 12.1 years, 1,520 individuals developed dementia, […]
A UK retrospective cohort study suggested that a favorable lifestyle was associated with a lower dementia risk among participants with high genetic risk. The study included a total of 196 383 individuals (mean 64.1 years; 52.7% women) from 2006 to 2010, and followed up for 1 545 433 person-years (median follow-up, 8.0 years). […]
The Global Council on Brain Health (GCBH), an independent collaborative of scientists, health professionals, scholars and policy experts from around the world who are working in areas of brain health related to human cognition concluded that there is no convincing evidence to recommend dietary supplements for brain health in healthy […]