A population-based study in Canada revealed that older adults who started proton pump inhibitors (PPIs) therapy had an increased risk of acute kidney injury and acute interstitial nephritis. The study included 290 592 individuals 66 years and older who initiated PPI therapy between Apr. 1, 2002, and Nov. 30, 2011. Propensity score matching were used to establish an equal number of highly comparable reference group of control patients. The primary outcome was hospital admission with acute kidney injury within 120 days, and a secondary analysis examined acute interstitial nephritis. The rates of acute kidney injury (13.49 v. 5.46 per 1000 person-years, respectively) and acute interstitial nephritis (0.32 vs. 0.11 per 1000 person-years) were higher among patients given PPIs than among controls. A growing body of literature suggests that PPIs use increase the risk of osteoporosis, acute interstitial nephritis and a risk that people won’t absorb certain vitamins and minerals such as magnesium, iron, B12 and calcium. Source: http://www.cmajopen.ca/一项加拿大的群体研究表明，老年人开始质子泵抑制剂治疗者急性肾损伤和急性间质性肾炎的风险增加。该研究共纳入290 592名66岁以上， 于2002年4月1日至2011年11月30日之间开始质子泵抑制剂治疗的患者，并以倾向得分匹配建立同等数量的对照组患者作为高度可比的参照群体。主要指标是120天内因急性肾损伤住院，次要指标是急性间质性肾炎。给予质子泵抑制剂治疗者急性肾损伤（分别是每1000人-年13.49和5.46）和急性间质性肾炎（每1000人 – 年0.32与0.11）的比率均较对照组高。越来越多的文献表明，使用质子泵抑制剂增加骨质疏松，急性间质性肾炎的风险，以及某些维生素和矿物质吸收障碍，如镁，铁，维生素B12和钙。来源：http://www.cmajopen.ca/
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