A cross-sectional study comprised 14,828 metabolically normal adults 30 to 59 years of age with no known cardiovascular disease in South Korea showed a higher prevalence of subclinical coronary atherosclerosis (coronary artery calcium scores ) in metabolically healthy obese (MHO) compared to metabolically healthy normal weight participants, supporting that MHO is not a harmless condition. The association was mediated by metabolic risk factors, such as LDL cholesterol, at levels below those considered abnormal. The results are consistent with a recent systematic review and meta-analysis, which concluded obese persons are at increased risk for adverse long-term outcomes even in the absence of metabolic abnormalities compared with their normal-weight counterparts. Source: http://content.onlinejacc.org/article.aspx?articleid=1864461; http://annals.org/article.aspx?articleid=1784291韩国一项包括14,828名代谢正常且无已知的心血管病的30〜59岁成人的横断面研究显示，与代谢和体重正常者相比，代谢正常的肥胖者亚临床冠脉硬化（冠脉钙化积分）患病率较高，支持代谢正常的肥胖并非无害的观点。其关联是由代谢危险因子，如低密度脂蛋白胆固醇，在低于被认为是异常的水平所介导的。该结果与最近一项系统综述和荟萃分析的结论一致，即与体重正常者相比肥胖者面临更大的不良长期预后的风险，即便无代谢异常。 来源: http://content.onlinejacc.org/article.aspx?articleid=1864461; http://annals.org/article.aspx?articleid=1784291
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