Blood Pressure Trajectories in Early Adulthood and Subclinical Atherosclerosis in Middle Age青年期血压轨迹与中年期亚临床动脉硬化

Prospective cohort data from 4681 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study, who were black and white men and women aged 18 to 30 years at baseline in 1985-1986 at 4 urban US sites, collected through 25 years of follow-up (2010-2011) showed that blood pressure (BP) trajectories throughout young adulthood vary, and higher BP trajectories were associated with an increased risk of coronary artery calcification in middle age . Associations were not altered after adjustment for baseline and year 25 BP. Findings were similar for trajectories of isolated systolic BP trajectories but were attenuated for diastolic BP trajectories.

BP typically increases with age, rising BP throughout middle and older age has been shown to significantly increase lifetime cardiovascular risk in a dose-response manner.一项在4681名18至30岁黑人和白人青年人群的前瞻性（CARDIA，始于1985-86年，随访至2010-11年）研究随访25年的资料表明，青年期的血压轨迹不等，较高的血压轨迹与中年期冠脉钙化风险的增高有关。该相关性经校正基础血压和25年后血压仍然不变。单纯收缩压轨迹的相关性亦然，而舒张压轨迹的相关性稍弱。

一般情况下血压会随年龄增大而升高。已有研究表明，中老年期血压增高越明显则一生的心血管病风险越大。