Mediterranean Diet Improves High-Density Lipoprotein Function地中海饮食改善高密度脂蛋白功能

A randomized controlled trial revealed that a traditional Mediterranean diet (TMD), especially when enriched with virgin olive oil, improved HDL atheroprotective functions in humans. The study compared the effects of 2 TMDs, one enriched with virgin olive oil (TMD-VOO; n=100) and the other enriched with nuts (TMD-Nuts; n=100), with respect to a low-fat control diet (n=96) after a 1-year intervention. Both TMDs increased cholesterol efflux (reverse cholesterol transport) capacity relative to baseline. The TMD-VOO intervention decreased cholesteryl ester transfer protein activity (relative to baseline) and increased HDL ability to esterify cholesterol, paraoxonase-1 arylesterase (antioxidant properties ) activity, and HDL vasodilatory capacity (relative to control, respectively). All 3 diets increased the percentage of large HDL particles (relative to baseline). Adherence to a TMD has been shown to reduce cardiovascular risk and the potential to reduce the progression of age-related macular degeneration. Source: http://circ.ahajournals.org/

一项随机对照试验显示，传统的地中海饮食，特别是当富含初榨橄榄油时，改善人高密度脂蛋白的保护功能。该研究比较了两种传统地中海饮食，一种富含初榨橄榄油（n=100）, 另一种富含坚果（n=100），相对于低脂肪对照饮食干预一年后的作用。相对于基线，两种传统的地中海饮食均增加胆固醇流出（反向胆固醇转运）能力。富含初榨橄榄油的传统地中海饮食干预降低胆固醇酯转移蛋白活性（相对于基线），并增加高密度脂蛋白酯化胆固醇的能力，增强对氧磷酶-1芳基酯酶（抗氧化性质）活性和高密度脂蛋白的血管扩张能力（分别相对于对照）。所有3种饮食均增加了高密度脂蛋白大颗粒的百分比（相对于基线）。坚持传统的地中海饮食已显示出降低心血管风险和减少年龄相关的黄斑变性发展的潜力。来源：http://circ.ahajournals.org/