A prospective study in the US concluded that higher levels of fitness at baseline and improvement in fitness early in adulthood are favorably associated with lower risks for cardiovascular disease (CVD) and mortality. Fitness and changes in fitness are associated with myocardial hypertrophy and dysfunction but not coronary artery calcification (CAC). The study included 4872 adults aged 18 to 30 years who underwent treadmill exercise testing from 1985. During median follow-up of 26.9 years, 273 (5.6%, the majority of noncardiovascular causes) died and 193 (4.0%) experienced CVD events. After comprehensive adjustment, each additional minute of baseline exercise test duration was associated with a 15% lower hazard of death and a 12% lower hazard of CVD. Higher levels of baseline fitness were associated with significantly lower left ventricular mass index and significantly better lobal longitudinal strain at year 25. Fitness was not associated with CAC. A 1-minute reduction in fitness by year 7 was associated with 21% and 20% increased hazards of death and CVD, respectively, along with a more impaired strain. No association between change in fitness and CAC was found. It is known that fitness is prognostic in older adults. Source: http://archinte.jamanetwork.com/
美国一项前瞻性研究得出结论，成年早期较高的基础健身水平及其改善有利于降低心血管病和死亡风险。健身水平及其变化与心肌肥厚和功能障碍相关，而非冠脉钙化。该研究包括4872名年龄在18至30岁的成年人，从1985年开始进行活动平板试验。在中位随访26.9年中，273人（5.6％，多为非心血管原因）死亡，193例（4.0％）发生心血管事件。全面校正之后，基础运动试验持续时间每增加一分钟与死亡风险低15％和心血管病风险低12％相关。较高的基础健身水平与第25年时左室质量指数显著降低和显著更好的节段性纵向应变相关，而与冠状动脉钙化无关。第7年时健身运动试验持续时间每减少一分钟分别与死亡和心血管病风险增加21％和20％相关，且伴随应变障碍。未发现健身水平的变化与冠脉钙化有关。已知老年人健身水平有预后意义。来源：http://archinte.jamanetwork.com/
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