Misaligned Sleep Timing Linked with Cardiometabolic Risk Factors睡眠时间不一致与心脏代谢风险因素有关

A study in the US found that a misalignment of sleep timing, namely social jetlag (SJL), is associated with metabolic risk factors that predispose to diabetes and atherosclerotic cardiovascular disease. The study included 447 healthy, midlife adults who worked part- or full-time day shifts, mean age 42.7 (range 30 –54) y; 53% female; 83% white. SJL was quantified as the difference (in minutes) between the midpoints of actigraphy-derived sleep intervals before work vs non-workdays. Multiple regression analyses showed that SJL of more than 60 minutes related to a lower high-density lipoprotein-cholesterol level, higher triglycerides, higher fasting plasma insulin, insulin resistance, and adiposity, even after adjustment for subjective sleep quality, actigraphy-derived sleep characteristics, depressive symptomatology, and health behaviors. Evening chronotype associated with lower high-density lipoprotein-cholesterol after adjustment for covariates, consistent with previous research that shift work is linked to increased incidence of cardiometabolic diseases. Source: http://press.endocrine.org/

美国一项研究发现，睡眠时间不一致，所谓社交时差，与易患糖尿病和动脉粥样硬化性心血管病的代谢危险因素相关。这项研究包括447名健康，兼职或全职白班的中年人，平均年龄42.7（范围30 -54）岁; 53％的女性; 83％是白人。 社交时差定量为（睡眠）活动仪测得的非工作日与工作日之前睡眠时间中点之间间隔的差值（单位为分钟）。多元回归分析表明，社交时差超过60分钟与较低的高密度脂蛋白胆固醇水平，较高的甘油三酯，空腹血浆胰岛素，胰岛素抵抗，和肥胖有关，经校正主观睡眠质量，（睡眠）活动仪测得的睡眠特征，抑郁症状和健康行为后亦然。经校正协变量后晚睡者高密度脂蛋白胆固醇较低，与以前的研究结果轮班工作与心血管代谢疾病的发病率增加有关一致。来源：http://press.endocrine.org/