A prospective study and meta-analysis identified prolonged sleep as a potentially useful marker of increased future stroke risk in an apparently healthy aging population. The study included 9,692 stroke-free participants aged 42–81 years in a British population. After 9.5 years of follow-up, 346 cases of stroke occurred. Long sleep (>8 hours) was significantly associated with an increased risk of stroke after adjustment for all covariates. The association remained robust among those without preexisting diseases and those who reported sleeping well. The association for short sleep (<6 hours) was smaller. There was a higher stroke risk among those who reported persistently long sleep or a substantial increase in sleep duration over time, compared to those reporting persistently average sleep (6-8 Hours). The results were compatible with that from an updated meta-analysis. The meta-analysis included additional 11 studies, about 560,000 participants. Over a follow-up of 7.5 to 35 years, close to 11,700 strokes were reported. The study adds to the growing body of evidence on the ties between sleep and stroke risk. It is not clear whether long sleep is a cause, consequence, or early marker of ill health. Source: http://www.neurology.org/一项前瞻性研究和荟萃分析确定久睡(>8小时）可作为显然健康的老人未来中风风险增加的有用指标。该研究纳入英国9692名年龄42-81岁且无卒中的参与者。经过9.5年随访，发生了346例脑卒中。经校正所有其它因素后，久睡与中风风险的增加显著相关。该相关性对无既有疾病且报告睡眠好者仍很强。短睡（<6小时）相关性较小。与报告长期平均睡眠（6-8小时）者相比较，报告长期久睡或睡眠时间随着时间的推移大幅增加者中风的风险更高。该研究结果与最新的荟萃分析一致。该荟萃分析包括了额外11项研究，约56万参与者。通过随访7.5年至35年，共报告近11700例脑卒中。有关睡眠和中风风险有关的证据越来越多，该研究是其中之一。目前尚不清楚久睡是脑卒中的原因，后果，或只是早期健康欠佳的标志。来源：http://www.neurology.org/
