Clarithromycin May Increase Risk of Cardiac Death克拉霉素可增加心源性死亡的风险

A national cohort study found a significantly increased risk of cardiac death associated with clarithromycin. The prospective study included Danish adults 40-74 years of age, who received seven day treatment courses with clarithromycin (n=160 297), roxithromycin (n=588 988), and penicillin V (n=4 355 309) between 1997-2011. Compared with use of penicillin V, use of clarithromycin was associated with a significantly increased risk of cardiac death but use of roxithromycin was not. The association with clarithromycin was most pronounced among women. The association between clarithromycin use and cardiac death was present only with current use of the drug. Source: http://www.bmj.com/一个全国性群组研究发现，克拉霉素与心源性死亡风险的显著增加有关。该前瞻性研究纳入了1997至2011年间丹麦40-74岁的成年人，分别使用了7天疗程的克拉霉素（160297人），罗红霉素（588988人），和青霉素V（4355309人）。与使用青霉素V者相比，使用克拉霉素与心源性死亡风险显著增加有关，而非罗红霉素。与克拉霉素的相关性以女性最为显着。克拉霉素的使用和心源性死亡之间的相关性只存在于当前使用该药者。来源：http://www.bmj.com/