A meta-analysis showed that there is an inverse dose-response relationship between physical activity (PA) and risk of heart failure (HF). Twelve prospective cohort studies with 20,203 HF events among 370,460 participants (>18 years of age, 53.5% women; median follow-up 13 years) were included in the analysis. Compared with participants reporting no leisure time PA, those who engaged in guideline recommended minimum levels of PA [500 Metabolic Equivalent of Task (MET)-min/week, the equivalent of 150 min/week of moderate-intensity PA, 2008 US Federal Guidelines] had modest reductions in HF risk. A substantial risk reduction was observed among individuals who engaged in PA at twice and four times the minimum guideline recommended levels. In contrast, an earlier study reported an inverse dose-response relationships between PA and the risk of coronary heart disease even at 250 MET-min/week and the risk reduction plateaued at higher than 1,000 MET-min/week. A recent study showed that PA below current recommendations reduced mortality by 22% in older adults. A further increase in physical activity dose improved these benefits in a linear fashion. Source: http://circ.ahajournals.org/; http://bjsm.bmj.com/
一项荟萃分析表明，体力活动和心衰风险呈反比的量效关系。该分析包括了12个前瞻性群组研究，共370460人（> 18岁，53.5％为女性;平均随访13年），20203 例心衰。与无闲暇时间体力活动者相比，按指导建议的最低水平体力活动者（500分钟任务代谢当量/周，相当于150分钟/周中等强度体力活动，2008年美国联邦指南）心衰风险适度减少。而从事最低推荐水平的两倍和四倍体力活动者心衰风险大幅降低。相反，先前有研究报道体力活动和冠心病，即使在250 分钟任务代谢当量/周亦呈反比的量效关系，高于1000分钟任务代谢当量/周则风险降低平稳。最近一项研究表明，低于目前推荐水平的体力活动降低了20%的老年人死亡率。更高的体力活动水平则更有益，且呈线性关系。来源：http://circ.ahajournals.org/；http://bjsm.bmj.com/
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