Lower SBP Reduces Atrial Fibrillation降低收缩压减少房颤

A post hoc study revealed that systolic blood pressure (SBP) ≤130 mm Hg is associated with a lower risk of new-onset atrial fibrillation (AF) in hypertensive patients with ECG left ventricular hypertrophy. The study included 8831 hypertensive patients with ECG left ventricular hypertrophy with no history of AF. Patients with in-treatment SBP ≤130 mm Hg and SBP between 131 and 141 mm Hg were compared with patients with in-treatment SBP ≥142 mm Hg. During follow-up of 4.6±1.1 years, new-onset AF was diagnosed in 701 patients (7.9%). In multivariate Cox analyses, compared with in-treatment SBP ≥142 mm Hg, in-treatment SBP ≤130 mm Hg entered as a time-varying covariate was associated with a 40% lower and in-treatment SBP of 131 to 141 mm Hg with a 24% lower risk of new AF. However, treating to lower SBP levels may increase other risk, especially in the elderly. Source: http://hyper.ahajournals.org/一项事后研究表明，收缩压≤130毫米汞柱与心电图左室肥厚高血压患者新发房颤的风险较低有关。该研究纳入8831名心电图左室肥厚且无房颤病史的高血压患者。治疗中收缩压≤130，131和141毫米汞柱的患者与≥142毫米汞柱的患者人进行了比较。在随访4.6±1.1年间，701例患者被诊断为新发房颤（7.9％）。经多变量Cox分析，与治疗中收缩压≥142毫米汞柱相比，把收缩压≤130毫米汞柱输入为随时间变化的协变量，与40％较低的新发房颤相关；而治疗中收缩压131至141毫米汞柱与24％较低的新发房颤相关。然而，治疗以降低收缩压水平可能增加其他风险，特别是在老年人中。来源：http://hyper.ahajournals.org/