Categories: 心血管病

Cardiotoxic Effects of Alcohol in the Elderly酒精对老年人的心脏毒性

A prospective observational study in the US concluded that in an elderly community-based population, increasing alcohol intake is associated with subtle alterations in cardiac structure and function, with women appearing more susceptible than men to the cardiotoxic effects of alcohol. The study correlated weekly alcohol consumption in 4,466 participants (76±5 years and 60% women, excluding former drinkers and those with significant valvular disease) to the structure and function of the heart. In both genders, increasing alcohol intake (0, ≤7, ≥7 to 14, and ≥14 drinks per week at visit 5 and time updated cumulative average alcohol consumption during 23.6±0.9 years) was associated with larger left ventricular diastolic and systolic diameters and larger left atrial diameter. In men, increasing alcohol intake was associated with greater left ventricular mass and higher E/E′ ratio. In women, increasing alcohol intake was associated with lower left ventricular ejection fraction and a tendency for worse left ventricular global longitudinal strain. The relationship between alcohol consumption and hypertension was U-shaped in both sexes. There was no significant trend in the prevalence of coronary artery disease by intake category. Excessive alcohol consumption is associated with cardiomyopathy while moderate drinking (generally defined as two alcoholic beverages a day for men and one for women) has been reported to be cardioprotective. Source: http://circimaging.ahajournals.org/美国一项前瞻性观察研究得出结论,以老年社区为基础的人群中,增加酒量与微妙的心脏结构和功能改变有关,且女性显得比男性对酒精的心脏毒性更敏感。该研究对4466名参与者(76±5岁,60%的妇女,排除曾饮酒者和有显著瓣膜病者)每周饮酒量与心脏的结构和功能进行了相关性分析。两性增加酒量(在第5次访问期间和23.6±0.9年间经按时更新的累积平均饮酒量每周0,≤7,≥7〜14,≥14份酒精饮料)均与较大的左心室舒张和收缩直径和较大的左心房直径相关。男性增加酒量与较大的左心室质量和较高的E / E’比值有关。女性增加酒量与较低的左心室射血分数和较差的左室整体纵向应变趋势有关。饮酒与高血压之间的关系则在两性均呈U形。各酒精摄入类别中冠心病的流行无显著趋势。过量饮酒与心肌病有关,而有报道适量饮酒(通常定义为男性每天两份,女性每天一份酒精饮料)有心脏保护作用。来源:http://circimaging.ahajournals.org/

hyangiu

近期博文

4:3间歇性禁食减肥效果优于每日热量限制

一项美国随机临床试验发现,对于…

2 天 ago

新型降糖药对老年二型糖尿病患者心血管病的效果比较

一项丹麦全国性队列研究提供的真…

1 周 ago

非手术与非介入疗法对腰痛的疗效

基于安慰剂对照的随机试验,一项…

2 周 ago

服用他汀类药物与肝癌及肝病进展风险降低有关

一项美国队列研究提示,服用他汀…

2 周 ago

颈动脉斑块的临床意义及其与年龄和性别的关系

一项美国队列研究提示,在没有临…

3 周 ago

用植物油取代黄油可提高生存率

一项基于美国人群的前瞻性队列研…

4 周 ago

This website uses cookies.