A long-term follow-up study in the US found that younger and middle-aged adults with isolated systolic hypertension (ISH) had higher relative risk for cardiovascular disease (CVD) and coronary heart disease (CHD) mortality than those with optimal-normal blood pressure (BP). ISH was defined as systolic blood pressure (SBP) ≥140 mm Hg and diastolic blood pressure (DBP) <90 mm Hg and optimal-normal BP was defined as SBP <130 mm Hg and DBP <85 mm Hg. The study included 15,868 men and 11,213 women 18 to 49 years of age (mean age 34 years) at baseline, 85% non-Hispanic white. During a 31-year average follow-up period (842,600 person-years), there were 1,728 deaths from CVD, 1,168 from CHD, and 223 from stroke. Cox proportional hazards models were adjusted for age, race, education, body mass index, current smoking, total cholesterol, and diabetes. With optimal-normal BP as the reference stratum, risks for CVD and CHD mortality for those with ISH were increased for both men and women. ISH is common in the elderly, although relatively uncommon in younger and middle-age adults but increasing in prevalence. Source: http://www.sciencedirect.com/美国一项长期随访研究发现，年轻人和中年人单纯收缩期高血压（ISH）的心血管病（CVD）和冠心病（CHD）死亡风险比那些具有最佳正常血压（BP）者相对较高。 ISH定义为收缩压（SBP）≥140毫米汞柱，舒张压（DBP）<90毫米汞柱；最佳正常血压定义为SBP<130毫米汞柱，舒张压<85毫米汞柱。这项研究开始时包括15868名男性和11213名女性，年龄18至49岁（平均年龄34岁），85％为非西班牙裔白人。在31年的平均随访期间（842600人年），共有1728人死于心血管病，1168死于CHD，223死于中风。 Cox风险比率模型对年龄，种族，教育，体重指数，当前吸烟状况，总胆固醇和糖尿病进行了校正。以最佳正常血压者为基准，那些ISH的男性和女性心血管病和冠心病的死亡风险均增加。 ISH常见于中老年人，虽然在年轻人和中年人中比较少见，但发生率在增加。来源：http://www.sciencedirect.com/
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