A cohort study of US adults over age 50 found that depressive symptoms were associated with increased stroke risk even if depressive symptoms remitted over a 2‐year period. Study participants (n=16 178, stroke free and noninstitutionalized at baseline) were interviewed biennially from 1998 to 2010. Adjusted marginal structural Cox proportional hazards were used and stratified by age, race or ethnicity, and sex. Stroke hazard was elevated among participants with stable high or remitted depressive symptoms compared with participants with stable low/no depressive symptoms. Stable high depressive symptom predicted stroke among all subgroups. Remitted depressive symptoms predicted increased stroke hazard among women and non‐Hispanic white participants and was marginally associated among Hispanics. The link between depression and stroke is well established. Biological mechanisms driving the depression-stroke link could be long term or short term. Source: http://jaha.ahajournals.org/一项美国50岁以上成年人的群体研究发现，抑郁症状与中风风险增加有关，即便抑郁症状在2年期间消退了亦然。研究参与者（16178名，无中风且自住者）从1998年至2010年间每两年采访一次，应用调整后的边际结构Cox风险比值并按年龄，种族或族裔和性别分类。与持续性低或无抑郁症状者比较，抑郁症状持续增高或已消退者中风的风险升高。抑郁症状持续增高预测了所有亚组的中风。抑郁症状消退者预测了妇女和非西班牙裔白人参与者中风风险的增加， 而西班牙裔仅轻微相关。抑郁症和中风之间的关系是公认的。导致抑郁和中风的生物学机制可以是长期的或短期的。来源：http://jaha.ahajournals.org/
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