A prospective cohort study in the US suggests that artificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia. The study included 2888 participants aged >45 y for incident stroke (mean age 62 y; 45% men) and 1484 participants aged >60 y for incident dementia (mean age 69 y; 46% men). Surveillance for incident events commenced between 1998 and 2001 and continued for 10 years. After adjustments for age, sex, education (for analysis of dementia), caloric intake, diet quality, physical activity, and smoking, higher recent and higher cumulative intake of artificially sweetened soft drinks were associated with an increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s disease dementia. When comparing daily cumulative intake to 0 per week (reference), the hazard ratios were 2.96 for ischemic stroke and 2.89 for Alzheimer’s disease. The results complement findings that sugar- and artificially-sweetened beverage intake were associated with poorer memory and smaller brain volumes from the same cohort. Source: http://stroke.ahajournals.org/
美国一项前瞻性群组研究表明，人造甜味软饮料消耗与卒中和痴呆风险较高相关。参与者包括卒中研究的2888名45岁以上者（平均年龄62岁; 45％男性）和痴呆研究的1484名年龄> 60岁者（平均年龄69岁;男性46％）。事件发生的监测于1998年至2001年间开始，持续了10年。经校正年龄，性别，教育（痴呆症分析），热量摄入量，饮食质量，身体活动和吸烟等之后，近期和累积人造甜味软饮料摄入量较高与缺血性卒中，全因痴呆和阿尔茨海默病痴呆的风险增加相关。当比较每日累积摄入量与0每周（参考）时，风险比分别为缺血性卒中的2.96和阿尔茨海默病的2.89。该结果与来自同一群组，糖和人造甜味饮料摄入与记忆力较差和脑容量较小相关的发现一致。来源：http://stroke.ahajournals.org/