A US study revealed that long-term antibiotic use in early-to-middle adulthood was associated with increased risk of colorectal adenoma, especially in the proximal colon. The study included 16 642 women aged ≥60 in 2004. There were 1195 cases of adenoma documented. Increasing duration of antibiotic use at age 20–39 and 40–59 was significantly associated with an increased risk of colorectal adenoma. Compared with non-users, women who used antibiotics for ≥2 months between age 20 and 39 had a multivariable OR of 1.36. Women who used ≥2 months of antibiotics between age 40 and 59 had a multivariable OR of 1.69. The associations were similar for low-risk versus high-risk adenomas, but appeared modestly stronger for proximal compared with distal adenomas. In contrast, recent antibiotic use within the past 4 years was not associated with risk of adenoma. The study is in line with prior studies of antibiotics and risk of colorectal cancer. Source: http://gut.bmj.com/
美国一项研究显示，成年早期至中期长期用抗生素与结肠直肠腺瘤的风险增加有关，特别是在近端结肠。该研究包括2004年的16 642名年龄≥60岁的女性。证实有1195例腺瘤。 20-39岁和40-59岁时抗生素使用时间延长与结肠直肠腺瘤风险增加显着相关。与未用者相比，20岁至39岁之间使用抗生素≥2个月的妇女的多变量风险比为1.36。 40岁至59岁之间使用≥2个月抗生素的妇女的多变量风险比为1.69。低风险与高风险腺瘤相关性类似，但与远端腺瘤相比，近端相对较强。相比之下，最近4年的抗生素使用与腺瘤风险无关。该研究与先前关于抗生素和结肠直肠癌风险的研究一致。来源：http://gut.bmj.com/