A randomized controlled trial in the UK suggested that a parent-mediated early social communication intervention was effective in a long term in autism spectrum disorder. Of the 152 trial participants aged 2–4 years with core autism, 121 (80%) were assessed between July, 2013, and September, 2014, nearly 6 years after the end of treatment. Mean age at follow-up was 10·5 years. Group difference in favor of the intervention based on the comparative severity score from the Autism Diagnostic Observation Schedule of log-odds effect size (ES) was 0·64 at treatment endpoint and ES 0·70 at follow-up, giving an overall reduction in symptom severity over the course of the whole trial and follow-up period (ES 0·55). Group difference in the Dyadic Communication Assessment Measure of the proportion of child initializations, when interacting with the parent at follow-up, showed a Cohen’s d ES of 0·29 and was significant over the course of the study (ES 0·33). There were no group differences in the language composite at follow-up (ES 0·15). The trial provided evidence that sustained improvements in autism symptoms can be possible after early intervention. Source: http://www.thelancet.com/
英国的一项随机对照试验表明，由父母介导的早期社交沟通干预对自闭症长期有效。在152名2-4岁核心孤独症的试验参与者中，在2013年7月至2014年9月，治疗结束后近6年，评估了121名（80％）。随访时平均年龄为10·5岁。基于自闭症诊断观察计划的严重程度比较评分，对数 – 几率效应值的组间差异有利于干预，治疗结束时为0.64，随访时为0.70，在整个试验和随访期间的症状严重程度（效应值0·55）减轻。随访中与父母进行互动时，由儿童开启的比例在互动交流测量评估的组间差异Cohen d 效应值为0·29，且在研究过程中是显着的（效应值 0·33）。随访时的语言组合无组间差异（效应值 0·15）。该试验为早期干预可能持续改善自闭症症状提供了证据。来源：http://www.thelancet.com/