A longitudinal cohort study suggested that calcium supplement use may increase the risk for atherosclerosis, as measured by coronary artery calcification (CAC), while calcium intake from dietary sources was associated with a decreased risk of incident atherosclerosis over long-term follow-up. The study included 5448 adults free of clinically diagnosed cardiovascular disease (52% female; aged 45–84 years). Baseline total calcium intake was categorized into quintiles. Baseline CAC was measured by computed tomography, and CAC measurements were repeated in 2742 participants ≈10 years later. After adjustment for potential confounders, among 1567 participants without baseline CAC, the relative risk (RR) of developing incident CAC over 10 years, by quintile 1 to 5 of calcium intake, were 1 (reference), 0.95, 1.02, 0.86, and 0.73. After accounting for total calcium intake, calcium supplement use was associated with increased risk for incident CAC (RR=1.22). No relation was found between baseline calcium intake and 10 year changes in log transformed CAC among those participants with baseline CAC >0. Source: http://jaha.ahajournals.org/
一个纵向群组研究提示，钙添加剂的应用可能增加动脉粥样硬化（通过冠脉钙化衡量）的风险，而膳食来源的钙摄入则与经长期随访的动脉粥样硬化的风险降低相关。该研究包括5448名无临床诊断的心血管病的成年人（52％为女性，年龄45-84岁）。基线钙摄入总量分为五个等级。基线冠脉钙化通过计算机断层扫描测量，且对2742名参与者约10年后重复冠脉钙化测量。经调整潜在混杂因素后，在无基线冠脉钙化的1567名参与者中，按基线钙摄入总量从1至5级，10年内发生冠脉钙化的相对风险比分别为1（对照），0.95, 1.02, 0.86和0.73 。经计入钙摄入总量后，钙添加剂的应用与冠脉钙化的风险增加相关（风险比 = 1.22）。而对基线冠脉钙化≥0的那些参与者，在基线钙摄入与对数转换的冠脉钙化的10年变化之间无关。来源：http://jaha.ahajournals.org/