A meta-analysis revealed that individuals carrying the FTO minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions. The analysis included eight randomized controlled trials (n=9563 individual participant data). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category. Those homozygous for the high-risk FTO genotype weigh 3 kg more on average and have a 1.7-fold increased odd of being obese compared to those with the low-risk genotype. Source: http://www.bmj.com/
一项荟萃分析表明，携带FTO次要等位基因者对基于膳食，身体活动，或药物减肥的干预措施反应相同，因此与FTO次要等位基因相关的肥胖遗传倾向者可至少部分地通过这些措施抵消。该分析包括八个随机对照试验（9563例参与者个人数据）。总体而言，FTO基因型之间对减肥干预措施在身体质量指数，体重和腰围变化的差异无显著不同。敏感性分析表明FTO基因型之间对减肥干预措施在体重指数，体重和腰围变化的差异并未因干预类型，干预时间长短，种族，样本大小，性别，基线体重指数和年龄段而有所不同。纯合子高危FTO基因型者平均加重3千克，与低危基因型相比肥胖机率增加1.7倍。来源：http://www.bmj.com/