Long-term exposure to the combination of even modestly lower LDL cholesterol (LDL-C) and systolic blood pressure (SBP) has the potential to “dramatically reduce” a person’s lifetime risk of cardiovascular disease. The study used genetic and cardiovascular risk factor data from 102,773 individuals who had participated in 14 prospective cohort or case-control studies. The participants were then divided into 4 groups based on genetic factors: the reference group, a group with an LDL-C genetic score below the median (resulting in lower LDL-C), a group with a SBP genetic score below the median (resulting in lower SBP), and a group with both LDL-C and SBP genetic scores below the median (resulting in both lower LDL-C and lower SBP). Compared to the reference group, subjects in the lower LDL-C group had 54.2% lower risk of the primary outcome (a composite of the first occurrence of either coronary death, non-fatal myocardial infarction, non-fatal stroke, or coronary revascularization.), those in the lower SBP group had 44.7% lower risk, and those in the combined lower LDL-C and SBP group had 86.1% lower risk. The new findings suggest that long-term exposure to the combined reduction of both 1 mmol/L in LDL-C and 10 mmHg SBP through lifestyle interventions and medication has the potential to “largely eliminate” the lifetime risk of cardiovascular disease. Source: http://www.escardio.org/
长期，甚至小幅下跌的低密度脂蛋白胆固醇和收缩压联合具有“显着减少”个人心血管病终生风险的潜力。该研究采用了参与14项前瞻性群组或病例对照研究的102773人的基因和心血管危险因素资料。然后根据遗传因素把参与者分为4组：对照组，低密度脂蛋白胆固醇遗传比分低于中位数组（导致低密度脂蛋白胆固醇较低），收缩压遗传比分低于中位数组（导致收缩压较低），以及低密度脂蛋白胆固醇和收缩压遗传比分均低于中位数组（导致低密度脂蛋白胆固醇和收缩压均较低）。与对照组相比，低密度脂蛋白胆固醇较低组参与者的主要预后（包括首次出现冠心病死亡，非致死性心梗，非致死性卒中或冠脉血运重建）的风险降低54.2％。收缩压较低组参与者的风险降低44.7％，而那些低密度脂蛋白胆固醇和收缩压均较低组参与者的风险降低86.1％。该新发现提示，通过生活方式干预和药物，长期使低密度脂蛋白胆固醇降低1毫摩尔/升和收缩压降低10毫米汞柱相结合具有“基本上消除”心血管病终生风险的潜力。来源：http://www.escardio.org/