An observational study in the US showed that a longer duration of overweight and obesity is associated with an increased risk of developing several forms of cancer. The degree of overweight experienced during adulthood seemed to play an important role in the risk of developing cancer, especially for endometrial cancer. A total of 73,913 postmenopausal women free of cancer at baseline were included in the study between October 1, 1993, and December 21, 1998, and 6,301 obesity-related cancers were diagnosed during a mean follow-up of 12.6 years. About two-thirds of all included women were ever overweight or obese during adulthood. Being overweight for a longer duration during adulthood significantly increased the incidence of all obesity-related cancers by 7% (for every ten-year increase in adulthood overweight duration), of postmenopausal breast cancer by 5%, and of endometrial cancer by 17%. After adjusting for the intensity of overweight, these figures rose to 8% for postmenopausal breast cancer and 37% for endometrial cancer. The findings suggest that reducing overweight duration in adulthood could reduce cancer risk and that early obesity prevention is important. Source: http://journals.plos.org/
美国一项观察性研究表明，超重和肥胖持续时间较长与发生几种癌症的风险增加有关。成年期间超重的程度似乎对发生癌症的风险有重要作用，尤其对子宫内膜癌。1993年10月1日至1998年12月21日间共纳入73913名无癌症绝经后妇女，平均随访12.6年期间共确诊6,301例与肥胖相关的癌症。所有包括的妇女中，大约三分之二成年时期曾经超重或肥胖。成年期超重持续时间较长（成年期超重每增加十年）显著增加所有肥胖相关癌症的发病率7％，绝经后乳腺癌为5％和子宫内膜癌的17％。经校正超重强度后，上述发病率增加升至绝经后乳腺癌的8％和子宫内膜癌的37％。该研究结果表明，减少成年后超重的持续时间可能会降低患癌症的风险，及早预防肥胖非常重要的。来源：http://journals.plos.org/