A multicenter, double-blind, placebo-controlled trial in the US revealed that treatment with high-dose omega-3 fatty acids in patients of acute myocardial infarction reduced adverse left ventricular remodeling, noninfarct myocardial fibrosis, and serum biomarkers of systemic inflammation. 358 patients with acute myocardial infarction , ages 21 and older, were randomly assigned to 4 grams of omega-3 fatty acids [containing ethyl esters of eicosapentaenoic acid (EPA, ≈465 mg) and docosahexaenoic acid (DHA, ≈375 mg, n=180) or placebo (corn oil, n=178) for 6 months between June 2008 and August 2012. Cardiac magnetic resonance imaging was used to assess cardiac structure and tissue characteristics. Patients assigned to omega-3 fatty acids experienced a significant reduction of left ventricular systolic volume index (–5.8%), and noninfarct myocardial fibrosis (–5.6%) in comparison with placebo. Those patients who achieved the highest quartile increase in red blood cell omega-3 index experienced a 13% reduction in left ventricular systolic volume index in comparison with the lowest quartile. In addition, patients in the omega-3 fatty acid arm underwent significant reductions in serum biomarkers of systemic and vascular inflammation and myocardial fibrosis. No adverse events associated with high-dose omega-3 fatty acid therapy. The study suggests that fish oil is safe and effective in improving cardiac remodeling after a heart attack. Source: http://circ.ahajournals.org/
美国一项多中心，双盲，安慰剂对照试验表明，急性心梗患者大剂量ω-3脂肪酸治疗减少了不良左室重构，非梗死心肌纤维化，和全身性炎症反应的血清标志物。 2008年六月至2012年八月间，358例年龄21岁以上的急性心梗患者被随机分配到4克ω-3脂肪酸[含有二十碳五烯酸乙酯（EPA，≈465毫克）和二十二碳六烯酸（DHA，≈375毫克，180名）或安慰剂（玉米油，178名）组治疗6个月。用心脏磁共振成像来评估心脏结构和组织特性。与安慰剂相比，ω-3脂肪酸组患者左心室收缩容积指数（-5.8％），和非梗死心肌纤维化（-5.6％）均显著减少。与红细胞ω-3指数增加最少的四分之一患者相比，红细胞ω-3指数增加最多的四分之一患者的左心室收缩容积指数降低了13％。此外，ω-3脂肪酸组患者的全身性和血管性炎症和心肌纤维化的血清标志物显著减少。没有与高剂量ω-3脂肪酸治疗相关的不良事件。该研究提示，鱼油对心梗后改善心脏重构安全有效。来源：http://circ.ahajournals.org/