A population-based prospective cohort study revealed that in a representative population sample of middle-aged men, low aerobic capacity was associated with increased mortality rates, independent of traditional risk factors, during more than 40 years of follow-up. The representative sample born in 1913 was followed from 50–99 years of age. At 54 years of age, 792 men performed an ergometer exercise test, with 656 (83%) performing the maximum exercise test. In Cox regression analysis, low predicted peak oxygen uptake (VO2max), smoking, high serum cholesterol and high mean arterial blood pressure at rest were significantly associated with mortality. In multivariable analysis, an association was found between predicted VO2max tertiles and mortality, independent of established risk factors. Hazard ratios were 0.79 for predicted VO2max, 1.01 for mean arterial blood pressure, 1.13 for cholesterol, and 1.58 for smoking. The variable impact (Wald’s χ2) of predicted VO2max tertiles (15.3) on mortality was secondary only to smoking (31.4). The risk associated with low predicted VO2max was evident throughout four decades of follow-up. The study suggests that being physically active can have a big impact over a lifetime. Source: http://cpr.sagepub.com/
一项基于人群的前瞻性群组研究经40多年的随访发现，在一个代表中年男性的人群样本中，低有氧代谢能力与死亡率增加有关，独立于传统的危险因素。对出生于1913年的该代表性人群从50岁随访至99岁。54岁时，792人进行了测力计运动试验，656人（83％）进行了极限运动试验。用Cox回归分析，预测的低峰值摄氧量（最大摄氧量），吸烟，高血清胆固醇和休息时高平均动脉压均与死亡率显著相关。多变量分析发现，预测的最大摄氧量四分位值和死亡率相关，独立于已知危险因素。风险比分别为预测最大摄氧量0.79，平均动脉压1.01，胆固醇1.13和吸烟1.58。预测最大摄氧量四分位变量对死亡率的影响（瓦尔德χ2 15.3）仅次于吸烟（31.4）。低预测最大摄氧量相关的风险显然贯穿四十年的随访。该研究表明，体力活动对一生有很大影响。来源：http://cpr.sagepub.com/