A prospective study concluded that high consumption of sweetened beverages may increase the risk of biliary tract cancer (BTC), particularly gallbladder cancer. The study included 70 832 Swedish adults (55.9% men, age 45-83 years) who were free of cancer and diabetes. Cox proportional hazards regression model was used to analyze the data. During a mean follow-up of 13.4 years, 127 extrahepatic BTC case patients (including 71 gallbladder cancers) and 21 intrahepatic BTC case patients were ascertained. After adjustment for other risk factors, women and men in the highest category of combined sugar-sweetened and artificially sweetened beverage consumption had a statistically significantly increased risk of extrahepatic BTC and gallbladder cancer. The multivariable hazard ratios for two or more servings per day (200 mL/serving) of sweetened beverages compared with no consumption were 1.79 for extrahepatic BTC and 2.24 for gallbladder cancer. The corresponding hazard ratio for intrahepatic BTC was 1.69. Sugar-sweetened beverage consumption raises blood glucose concentration and has been positively associated with weight gain and type 2 diabetes, which have been linked to BTC. Source: http://jnci.oxfordjournals.org/
一项前瞻性研究认为，多饮甜饮料可能增加胆道癌的风险，尤其是胆囊癌。这项研究包括70 832名无癌症和糖尿病的瑞典成年人（55.9％为男性，年龄45-83岁）。 用Cox比例风险回归模型对数据进行分析。在平均13.4年的随访期间，共确定了127例肝外胆道癌（包括71例胆囊癌）和21例肝内胆道癌患者。经校正其他危险因素，饮用加糖和人工甜味剂饮料最多的男性和女性肝外胆道癌和胆囊癌的风险显著增加。与未饮用者相比，每天饮用两份或更多份（200毫升/份）甜饮料的多变量风险比值为肝外胆道癌的1.79和胆囊癌的2.24。肝内胆道癌的相应风险比值为1.69。含糖饮料升高血糖浓度，并与体重增加和2型糖尿病正相关，这些均与胆道癌有关。来源：http://jnci.oxfordjournals.org/