A high normal body mass index (BMI) during adolescence was associated with increased cardiovascular and all-cause mortality during 40 years of follow-up. The study included 2.3 million Israeli adolescents (mean age, 17.3 years) between 1967 and 2010. During 42,297,007 person-years of follow-up, 9.1% deaths were from cardiovascular causes. On multivariable analysis, there was a graded increase in the risk of death from cardiovascular causes and all causes that started among participants in the high normal group (50th to 74th percentiles of BMI). Risks of death from cardiovascular causes in the obese group (≥95th percentile for BMI), as compared with the reference group (5th to 24th percentiles) increased from 2 times during follow-up for 0 to 10 years to 4 times during follow-up for 30 to 40 years. Source: http://www.nejm.org/
青春期高正常体重指数与40年的随访期间心血管和全因死亡率增加有关。该研究包括1967至2010年间以色列的230万青少年（平均年龄17.3岁）。在42297007人 – 年的随访中，9.1％的死亡是心血管原因。多变量分析显示，从高正常组（体重指数50至74百分位）开始，参与者心血管和全因死亡的风险成比例增加。与对照组（体重指数5至24百分位）相比，肥胖组（体重指数≥95百分位数）心血管病死亡的风险，从随访0至10年期间增加2倍至随访30至40年期间增加4倍。来源：http://www.nejm.org/