A Finnish population-based study concluded that individuals with hypercholesterolemia and hypertension who fail to take their prescribed statin and antihypertensive medication experience a substantially increased risk of fatal stroke. According to Finnish national registers in 1995 to 2007, the study included 58,266 hypercholesterolemia patients age 30+ years without pre-existing stroke or cardiovascular disease, 532 patients died of stroke (cases), and 57,734 remained free of incident stroke (controls) during the mean follow-up of 5.5 years. In all hypercholesterolemia patients, the adjusted odds ratio for stroke death for nonadherent compared with adherent statin users was 1.35 4 years before and 2.04 at the year of stroke death or the end of the follow-up. In hypercholesterolemia patients with hypertension, relative to those who adhered to statins and antihypertensive therapy, the odds ratio at the year of stroke death was 7.43 for those nonadherent both to statin and antihypertensive therapy, 1.82 for those non-adherent to statin but adherent to antihypertensive therapy, and 1.30 for those adherent to statin, but nonadherent to antihypertensive therapy. Source: http://www.sciencedirect.com/
一项芬兰人群研究的结论是，高胆固醇和高血压患者不服用处方他汀类和降压药则致命性中风的风险大大增加。根据1995年至2007年的芬兰国家记录，该研究共纳入58266例高胆固醇血症患者，年龄30岁以上而无中风或心血管病；平均5.5年的随访期间532例死于中风，57,734例无中风者为对照。在所有的高胆固醇血症患者中，与服用处方他汀类药者相比，不服用者校正后的中风死亡比例分别为前4年的1.35倍和卒中死亡当年或随访结束时的2.04倍。在高胆固醇的高血压患者中，相对于那些坚持他汀类药物和降压治疗者，卒中死亡当年不服用处方他汀类和降压药者比例为7.43倍，不服用处方他汀类但服用降压药者为1.82倍，服用他汀类药物但不服从降压治疗者为1.30倍。来源：http://www.sciencedirect.com/