The Oslo cardiovascular study revealed that a healthy life style led to a long term reduced coronary mortality for 40 years. The study included 1,232 middle-aged men who had total serum cholesterol levels of 7.5-9.8 mmol/l (290-380 mg/dl), and the majority (80%) were smokers. They were randomized into to a 5-year trial in the early 1970s. During twice-yearly clinical visits, men in the intervention group were advised to lower their saturated fat intake and increase consumption of fish, fruits, and vegetables. Overweight men were advised to lose weight, and smokers were advised to stop smoking. Men in the control group were given the same advice 8.5 years later. During follow-up, the beneficial effect developed gradually but proportionally up to about 15 years after randomization. Later, the curves were parallel. All-cause mortality decreased in the period 8–20 years after randomization, but not thereafter. However, there was still a 29% reduced risk of death at first myocardial infarction 40 years later. Source: http://onlinelibrary.wiley.com/；http://www.thelancet.com/
奥斯陆心血管研究表明，健康的生活方式导致冠心病的死亡率降低长达40年。这项研究包括1232名中年男性，血清总胆固醇水平7.5-9.8毫摩尔/升（290-380毫克/分升），大多数（80％）是吸烟者。他们在70年代初被随机分组至一个5年的试验。在每年两次就诊时，干预组被告知降低其饱和脂肪的摄入量，增加鱼，水果和蔬菜的消费。超重的男性被告知减肥，并劝告吸烟者戒烟。对照组则在8.5年后给予同样的建议。在随访期间，有益的效应逐步显现，且呈比例发展，直到随机分组后约15年。此后，两组曲线平行。全因死亡率在随机化后8-20年间降低，而非此后。然而，40年后首次心肌梗塞死亡的风险仍然降低29％。来源：http://onlinelibrary.wiley.com/；http://www.thelancet.com/