A prospective study revealed that coronary computed tomography angiography (CTA) and quantitative coronary angiography (QCA) exhibited similar diagnostic performance for the detection and exclusion of lesion-specific ischemia. The study included 252 patients from 5 countries (mean age 63 years; 71% male). Patients underwent coronary CTA and invasive coronary angiography with fractional flow reserve (FFR) in 407 lesions. Stenosis ≥50% was considered anatomically obstructive. Lesion-specific ischemia was defined according to FFR ≤0.8, whereas QCA and coronary CTA stenosis ≥50% were considered obstructive. According to FFR, ischemia was present in 151 (37%) of 407 lesions. Diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 69%, 79%, 63%, 55%, and 83% for coronary CTA; and 71%, 74%, 70%, 59%, and 82% for QCA. CTA is much less invasive, safer, and less expensive. Source: http://imaging.onlinejacc.org/
一项前瞻性研究发现，冠脉CT血管造影和定量冠脉造影对特定病灶缺血的检测与排除显示出相似的诊断性能。该研究包括来自5个国家252名患者（平均年龄63岁，71％为男性）。对患者的407处病变进行冠脉CT血管造影和冠脉介入造影及血流储备分数检测。狭窄≥50％被认为是解剖性梗阻。血流储备分数≤0.8定为特定病灶缺血，而定量冠脉造影和冠脉CT造影狭窄≥50％被认为是阻塞性的。根据血流储备分数，在407处病灶中的151处（37％）存在缺血。冠脉CT血管造影的诊断准确度，灵敏度，特异性，阳性预测值和阴性预测值分别为69％，79％，63％，55％，和83％， 而定量冠脉造影分别为71％，74％，70％，59％，和82％。 冠脉CT血管造影侵入性小得多，更安全，也更便宜。来源：http://imaging.onlinejacc.org/