A large-scale prospective study in the US suggests that long-term ambient O3 contributes to risk of respiratory and circulatory mortality. A total of 669,046 participants enrolled in 1982 were analyzed among which 237,201 deaths were observed through 2004. Cox proportional hazards regression models were used to examine mortality associations adjusted for individual- and ecological-level covariates. In single-pollutant models, there were significant positive associations between O3, PM2.5, and NO2 with all-cause and cause-specific mortality. In two-pollutant models adjusting for PM2.5, significant positive associations remained between O3 and all-cause, circulatory, and respiratory mortality that were unchanged with further adjustment for NO2. There were also positive mortality associations observed with both PM2.5 (both near-source and regional) and NO2 in multi-pollutant models. Source: http://www.atsjournals.org/
美国一个大型的前瞻性研究表明，环境中长期存在的臭氧增加呼吸和循环死亡风险。对669046名1982年加入者进行了分析，到2004年其中237201人死亡。采用Cox比例风险回归模型，校正了个人 – 和生态层面的协变量以研究与死亡率的关系。单污染物模型中，臭氧，PM2.5和二氧化氮与全因和特定原因死亡率呈显著正相关。双污染物模型中经校正PM2.5，臭氧仍与全因，循环，呼吸死亡率呈显著正相关，进一步校正了二氧化氮仍然如此。多污染物模型中PM2.5（包括近源和地区性）和二氧化氮也均与死亡率呈正相关。来源：http://www.atsjournals.org/