A meta-analysis revealed that macrolide antibiotics are associated with increased risk of sudden cardiac death (SCD) or ventricular tachyarrhythmias (VTA) and cardiovascular death. Thirty-three studies involving 20,779,963 participants were included in the analysis. Patients taking macrolides, compared with those who took no macrolides, experienced an increased risk of developing SCD or VTA, SCD, and cardiovascular death. The associations were noted for azithromycin, clarithromycin and erythromycin, but not for roxithromycin. No association was found between macrolides use and all-cause death or any cardiovascular events. Source: http://content.onlinejacc.org/
一项荟萃分析表明，大环内酯类抗生素与心源性猝死或室性心律失常和心血管死亡的风险增加有关。该分析共纳入三十三个研究，涉及20779963名参与者。服用大环内酯类药的患者与未服用者相比，发生心源性猝死或室性心律失常，心源性猝死和心血管死亡的风险增加。相关药物包括阿奇霉素，克拉霉素和红霉素，而非罗红霉素。未发现大环内酯类抗生素的使用和全因死亡或心血管事件相关。来源：http://content.onlinejacc.org/