A Swedish registry-based study found that mortality among persons with type 2 diabetes (T2D) varied greatly depending on age, glycemic control, and renal complications. The study included patients with T2D who were registered in the Swedish National Diabetes Register on or after January 1, 1998. For each patient, five controls were randomly selected from the general population and matched according to age, sex, and county. The mean follow-up was 4.6 years in the T2D group and 4.8 years in the control group. Overall, 77,117 of 435,369 patients with T2D (17.7%) died, as compared with 306,097 of 2,117,483 controls (14.5%). The excess risks of death from any cause and cardiovascular death increased with younger age, worse glycemic control, and greater severity of renal complications. As compared with controls, the risk of death from any cause among patients younger than 55 years of age who had a glycated hemoglobin level of 6.9% or less was significantly increased but not among patients older than 75 years of age or older. Among patients with normoalbuminuria, the risk of death among those younger than 55 years of age with a glycated hemoglobin level of 6.9% or less, as compared with controls, was significantly higher while the risk of death was significantly lower among patients older than 75 years of age or older, and patients 65 to 75 years of age. Source: http://www.nejm.org/
瑞典一项基于注册的研究发现，2型糖尿病患者死亡率变化很大，取决于年龄，血糖控制和肾脏并发症。这项研究包括1998年1月1日或以后瑞典国家糖尿病注册的2型糖尿病患者，对 每一个病人，随机从普通人群中根据年龄，性别，县选择五个对照匹配。平均随访糖尿病组4.6年和对照组4.8年。总体而言，435369例2型糖尿病患者中77117例（17.7％）死亡，而 2117483例对照者306097 例（14.5％）死亡。任何原因死亡和心血管死亡的风险随着年龄较小，血糖控制较差，和更严重的肾脏并发症而增加。与对照组相比，年龄小于55岁且糖化血红蛋白水平6.9％或更低的患者任何原因死亡的风险显著增加，而非年龄大于75岁或以上的患者。与对照组相比，年龄小于55岁，尿白蛋白正常且糖化血红蛋白水平6.9％或更低的患者任何原因死亡的风险显著升高，而年龄75岁或以上和65至75岁的患者死亡的风险显著降低。来源：http://www.nejm.org/