A large prospective cohort study in Norway found that maternally reported gastrointestinal (GI) symptoms are more common and more often persistent during the first 3 years of life in children with autism spectrum disorder (ASD) than in children with typical development (TD) or developmental delay (DD). The study included 114 516 children born from January 1, 2002, through December 31, 2008, with completed age 18- and 36-month questionnaires. Children with ASD were at significantly increased odds of maternally reported constipation and food allergy/intolerance in the 6- to 18-month-old age period and diarrhea, constipation, and food allergy/intolerance in the 18- to 36-month-old age period compared with children with TD. Similar results for these symptom categories were observed in comparisons with children with DD. Mothers of children with ASD were significantly more likely to report 1 or more GI symptom in either the 6- to 18-month or the 18- to 36-month-old age period and more than twice as likely to report at least 1 GI symptom in both age periods compared with mothers of children with TD or DD. GI comorbidities are frequently described in association with ASD. Source: http://archpsyc.jamanetwork.com/挪威的一项大型前瞻性群组研究发现，自闭症儿童前3年母亲报告胃肠道症状比发育正常或发育迟缓者较为常见，且往往持续。这项研究包括2002年1月1日至2008年12月31日间出生的114 516名儿童，并完成了年龄18和36个月的问卷调查。与发育正常儿童相比，自闭症儿童在6到18个月年龄段母亲报告便秘和食物过敏/不耐受，以及在18到36个月年龄段母亲报告腹泻，便秘，和食物过敏/不耐受的机率显著增加。与发育迟缓儿童相比结果类似。与发育正常或发育迟缓儿童母亲相比，自闭症儿童的母亲们在6〜18个月或18到36个月年龄段报告1或多种胃肠道症状的可能性显著增大，且超过两倍的可能性在两个年龄段均报告至少1 种胃肠道症状。 经常有胃肠道合并症与自闭症有关的报道。来源：http://archpsyc.jamanetwork.com/
